The Kelsh Lab

Robert Kelsh Lab's Fishy Business

Brigite Simoes Rodrigues

📥  lab news, PhD viva

IMG_2637smIMG_2667smallI was delighted to travel to Faro last week as part of the committee at Brigite's PhD viva. Brigite did very well and is now a thoroughly deserved 'Doctor', having manged to submit and correct a very substantial thesis despite having a child, moving country and taking up a post working on the ZCre project. Congratulations, Brigite!

BSR viva2smallIt was wonderful to meet old friends - our long-term collaborators from the Algarve, Leonor Cancela and Natercia Conceicao (left and right of Brigite), and from Lisbon, Antonio Jacinto (very colourful robe on the right) - and new - thanks to Jose Conde Belo, Rui Canceicao Martinho, Alexandra Carmo (left, in order) and Antonio Jacinto for doing a thorough job of 'vivaing' Brigite.

It's always interesting seeing how PhD vivas are done in other countries - especially when they are public like they are in Portugal. It was even more enjoyable to be there as a supervisor, and so not have the responsibility of questioning the candidate. A public viva is certainly more of an occasion, but probably even more stressful for the candidate - and for the examiners!


Marie Curie Success

📥  lab news

Very excited that Deeya Ballim will be joining the lab soon - we have just heard that her application for a Marie Sklodowska-Curie Incoming Fellowship Project 'Sox10mutants' has been successful. Well done, Deeya!


How potent is the neural crest?

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📥  Uncategorized

Pentimento: Neural Crest and the origin of mesectoderm

Jim Weston and Jean Paul Thiery have produced a detailed, careful and clearly-written summary of their 'metablast' hypothesis, in which they argue that neural crest does not, after all, form the skeletogenic (ectomesenchyme or mesectoderm) lineages. A revolutionary hypothesis, of course, but looking very plausible. Well worth a read.


Recent Paper

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📥  Developmental biology, Papers, Pigment pattern formation, Zebrafish genetics

Recent paper published in Pigment Cell Melanoma Res. (Dec 2014) doi: 10.1111/pcmr.12335.

Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms

Ceinos RM, Guillot R, Kelsh RN, Cerdá-Reverter JM, Rotllant J

Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, agouti-signalling peptide (ASIP). In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. In contrast, mechanisms driving the dorso-ventral countershading pattern have been overlooked. Here, we demonstrate that, in fact, zebrafish utilize two distinct adult pigment patterning mechanisms - an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell-cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes ASIP. These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern.