The Kelsh Lab

Robert Kelsh Lab's Fishy Business

Topic: Pigment pattern formation

Recent Paper

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📥  Developmental biology, Papers, Pigment pattern formation, Zebrafish genetics

Recent paper published in Pigment Cell Melanoma Res. (Dec 2014) doi: 10.1111/pcmr.12335.

Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms

Ceinos RM, Guillot R, Kelsh RN, Cerdá-Reverter JM, Rotllant J

Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, agouti-signalling peptide (ASIP). In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. In contrast, mechanisms driving the dorso-ventral countershading pattern have been overlooked. Here, we demonstrate that, in fact, zebrafish utilize two distinct adult pigment patterning mechanisms - an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell-cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes ASIP. These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern.