HCA combines cell biology with automated microscopy and data evaluation. For example information on a cellular event is acquired spatially and temporally and then automatically quantified. Spatially resolved instruments are typically automated microscopes, and temporal resolution requires some form of fluorescence measurement. Many HCA instruments are (fluorescence) microscopes connected to an image analysis package.
The GE Healthcare IN Cell Analyzer 2000 recently installed in MAS may be used for the detailed study of cellular mechanisms and interactions in multiple samples, for example, studying whether cell division, motility, or protein entry is affected when cells are exposed to external stimuli such as chemical inhibitors. Information generated using HCA is highly valuable in the study of complex diseases. In drug discovery research, the throughput gained using HCA makes it a valuable technology for drug target identification.
The GE Healthcare IN Cell Analyzer 2000 features include:
- A flexible, modular, lamp based cellular and subcellular imaging system.
- Automated imaging in fixed and live cells.
- High performance hardware and state of the art software for cell analysis.
The IN Cell Analyzer 2000 HCA is housed in its own room in MAS (2.14) and an analysis workstation is also available.