PharmNews

News from Pharmacy and Pharmacology at the University of Bath

A Summer of Research for Students from Shandong University

📥  Research

This summer the Department of Pharmacy & Pharmacology is hosting 5 undergraduate students from Shandong University, Jinan, to carry out 8 week research placements. IMG_1316 for blog The 5 students (left to right) Ziyu Zeng, Liguo Wang, Shiyu Zhou, Yafei Yu, and Xiaowen Ma, were selected on the basis of their academic record and an interview to participate in the Vacation Studentship Scheme. They are carrying out projects in the research groups of Drs Ian Eggleston, Matthew Lloyd, Ian Blagbrough and Amanda Mackenzie, and Prof Randy Mrsny in Pharmacy & Pharmacology , and in collaboration with other laboratories in the Faculty of Science. This is the fifth year that the Department has hosted a group of students from Shandong, through this scheme coordinated by the University International Relations Office and English Language Centre, with support from the Faculty of Science.

 

The fate of Mandelic Acid in Human Cells

📥  Research

The latest paper from the research group of Matthew Lloyd and colleagues, looking at the processing of a chemical called mandelic acid. Mandelic acid, an alpha-hydroxyacid, is used in the cosmetics industry in chemical skin peels.

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Matthew Lloyd

Mandelic acid exists as two different mirror image forms (known as the R- and S- enantiomers). In humans and other mammals it has been known for a long time that S-mandelic acid is converted into R-mandelic acid but not vice versa. Other workers proposed that this process was carried out by the same pathway that performs a similar transformation with anti-inflammatory drug Ibuprofen. This latest paper investigates this proposal and shows that mandelic acid is not processed by the same pathway as Ibuprofen.

The paper is the first from the work of Maksims Yevglevskis on this project, who is in the final stages of his PhD in the Department. Three of the other authors, Cat Bowskill, Chloe Chan and Justin Heng, performed work reported in this paper as part of their final year project (2012-13) for their Masters in Pharmacy degree.

The paper can be found at:

http://pubs.rsc.org/en/Content/ArticleLanding/2014/O/C3OB42515K#!divAbstract

 

 

 

3 Academic Staff Promoted to Senior Lecturer

📥  Teaching and Learning

The Academic Staff Committee have approved the promotion of three colleagues from Lecturer to Senior Lecturer. Congratulations to Dr Chris Bailey, Dr Nikoletta Fotaki and Dr Charareh Pourzand !

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Dr Chris Bailey (Senior Lecturer)

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Dr Nikoletta Fotaki (Senior Lecturer)

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Dr Charareh Pourzand (Senior Lecturer)

 

PhD student wins two prizes

📥  Prize, Research

Wing Chiu, PhD student, has now won two major prizes for a poster titled:

Visualising drug delivery to the nail with confocal and stimulated Raman scattering (SRS) microscopy
Authors: Wing Sin Chiu, Natalie A. Belsey, Natalie L. Garrett, Julian J. Moger, Gareth J. Price, M. Begoña Delgado-Charro, Richard H. Guy

The prizes are:

1) APS Industrial Insights 2014
16th-17th April 2014, AstraZeneca, Alderley Park, Cheshire

2) Skin forum 13th Annual Meeting
25-26 June 2013, UCL School of Pharmacy, London

Wing is co-supervised by Begona Delgado-Charro (P&P), Richard Guy (P&P) and Gareth Price (Chemistry).

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Visualising drug delivery to the nail with confocal and stimulated Raman scattering (SRS) microscopy

 

A Cheque from the Abseilers

📥  Charity

Prof. Mike Threadgill and Dr. Amit Nathubhai who recently took part in an abseiling event with Bath students presented a cheque to Yasmin Burtally from the Association of International Cancer Research. Also present was the Vice Chancellor, Don Foster and the Mayor of Bath. It was a double celebration as Katerina Kumpan, a PhD student of the Threadgill laboratory passed her viva on the same day.

AICR-cheque-presentation

Presentation of the cheque to AICR (Yasmin Burtally from AICR, Tim Higgs from Bath SU, and Amit Nathubhai from the Department of Pharmacy and Pharmacology)

 

 

 

 

 

 

 

 

 

 

 

 

 

For more photos of the volunteers evening see https://www.flickr.com/photos/bathsuphotos/

For more information about the volunteers at Bath SU see http://www.bathstudent.com/volunteer/

Follow on Twitter @BathUniVol

 

An audience with Mr Dispenser

📥  Humour

The PSA, BPSA and Royal Pharmaceutical Society Local Practice Forum have organised a light hearted evening of humour and anecdote with Mr Dispenser, author of "Pills, Thrills and Methadone Spills" on Friday 4th April at 19.30 in 5W 2.3. Over the last couple of years Mr Dispenser has developed a massive online following and is a very amusing speaker.

Coffee and cookies will be available from 19.00 in 5W Foyer. To book a place:

http://www.rpharms.com/events-calendar/event/157/an-audience-with-mr-dispenser

or email Sarah Wild (svw21@bath.ac.uk) if NOT a member/student member of the Royal Pharmaceutical Society.

ThrillsSpills

 

Mr Dispenser's blog is:
mrdispenser.wordpress.com

Twitter:
https://twitter.com/MrDispenser

Facebook:
https://www.facebook.com/pages/Mr-Dispenser/338975592792899

 

2014 Royal Pharmaceutical Society Prize Lecture

📥  Prize, Teaching and Learning

The 2014 Royal Pharmaceutical Society Prize Lecture was presented on 11th March by Patricia Wright, Chief Executive at the Royal College of Physicians.  During a wide-ranging lecture, Ms Wright, a 1981 Bath BPharm graduate, talked about the opportunities and challenges facing our MPharm graduates today as they enter their profession.  At the start of lecture, the Royal Pharmaceutical Society Prize for best MPharm3 student 2012-13 was presented to Magnus Hoffman by Ms Wright.

Magnus Hoffman with Ms Wright

Magnus Hoffman receiving the RPS prize from Ms Wright

 

World-Class Brain Research at Bath

📥  Uncategorized

Have you wondered what your brain looks like, and how a healthy brain should look?

The department is involved with two upcoming events about the brain that answers these questions:

"Looking at the Brain: Brain Scans and Brain Waves" - Public lecture by Prof. Roland Jones on 11th March

"The Art of the Brain" - A "sci-art" exhibition by artist Stephen Magrath, March 6th-25th. The project raises awareness among the public about world-class brain research being undertaken at the University of Bath.

dancing-neurons-stephen-magrath brain-stephen-magrath

Both events are at the Bath Royal Literacy & Scientific Institute, 16 Queen Square, Bath, BA1 2HN

About Us

"The Art of the Brain" where science meets art (L:R) Roland Jones, Chris Bailey, Stephen Magrath, Denise Taylor, Stephen Husbands, Sarah Bailey. Photo by Nic Delves-Broughton, University of Bath

"The Art of the Brain" where science meets art (L:R) Roland Jones, Chris Bailey, Stephen Magrath, Denise Taylor, Stephen Husbands, Sarah Bailey. Photo by Nic Delves-Broughton, University of Bath

How does stress affect the brain? Sarah Bailey Anxiety and depression affect more than 12 million adults in the UK. An interaction between the environment an individual is exposed to, together with their genetic make-up, likely determines brain chemistry and whether individuals are susceptible to these diseases. Research in my laboratory is trying to understand the brain’s response to stress with a view to developing new drug treatments.  http://www.bath.ac.uk/pharmacy/contacts/academics/sarah_bailey/

Understanding addiction Chris Bailey Around 2 million people in the UK have an addiction, either to legal drugs like alcohol or tobacco or illegal substances like heroin or cocaine. Treatment for addiction is poor – around 75% of quit attempts fail within a year. Research in my laboratory is trying to understand the mechanisms underlying addiction – when and how does infrequent drug use become addictive, compulsive drug use? http://www.bath.ac.uk/pharmacy/contacts/academics/chris_bailey/

Drug discovery in the brain Stephen Husbands My interest, as a chemist, is in designing and making new molecules that can help normalize dysfunctional activity in the brain and hopefully provide insight into, and new treatments for, drug abuse and depression.http://www.bath.ac.uk/pharmacy/contacts/academics/stephen_husbands/

What causes epilepsy? Roland Jones My main interest for the past 20 years has been trying to understand how communication between brain cells goes wrong in epilepsy. Whilst most sufferers have their seizures controlled by available drugs, about 30 per cent do not respond. It is essential that we understand the changes in the brain that lead to seizure activity, so that we can design and produce effective treatments for patients. http://www.bath.ac.uk/pharmacy/contacts/academics/roland_jones/

Exploring the effects of dementia Denise Taylor My research explores the positive and negative effects of medicines for dementia from the perspective of people with dementia, their carers and healthcare professionals. Dementia is not all about memory – it affects personality, problem solving, communication and social relationships – and so do the medicines. I believe the more we know about an illness the more we can help and support those people living with it. http://www.bath.ac.uk/pharmacy/contacts/academics/denise_taylor/

Find out more about brain research at the University of Bath: http://www.bath.ac.uk/neuroscience

Follow the Department of Pharmacy & Pharmacology on Twitter: @PharmUnivBath

After your visit to the exhibition, you can leave feedback via our online survey https://www.surveymonkey.com/s/GVSWSD7

Why not leave a comment below

 

Smarty Pants

📥  Charity, Research

Over £4000 Raised for Cancer Research

Simon-Mike-Amit-Olivia

Congratulations to Smarty Pants Fundraisers: Simon, Mike, Amit and Olivia

Prof. Mike Threadgill (PI) and Dr. Amit Nathubhai (Co-PI) have been awarded a grant from the charity, AICR (Association of International Cancer Research) to support their research towards the inhibition of Tankyrase and its link to cancer. They have recently supported a fund raising event called “Smarty Pants” created by AICR. Students from the University of Bath including those from the Department of Pharmacy and Pharmacology (Olivia Stillwagon and Simon Underwood), as well as Dr Amit Nathubhai and Prof. Mike Threadgill took part in an abseiling event down a 200ft descent off the Avon Gorge. Over £4000 has been raised.

Please see the following links below for recent publications, Smarty Pants twitter feed and to donate through just giving.com

Design and Discovery of 2-Arylquinazolin-4-ones as Potent and Selective Inhibitors of Tankyrase

Smarty Pants Twitter Feed

* * Donate **

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Mike Threadgill goes over the edge

amit-nathubhai-abseil

Amit Nathubhai poses for the camera in his Smarty-Pants

 

P&P Research Presentation at TEDx

📥  Uncategorized

Researchers in our department have created an innovative ingredient for suncream which can act as a UVA filter and provide fuller protection against skin damage. Dr Charareh Pourzand will be presenting her research at the TEDx Bath University Event on the 8th March:

The Skin ‘Beauty’ and the Sun ‘Beast’

While many suncreams provide good protection against the sun's UVB rays, the chief cause of skin reddening and sunburn, they provide less protection against more prevalent UVA rays. Scientists believe this may be one of the reasons why skin cancer incidence rates are increasing worldwide. Dr Charareh Pourzand and Dr Ian Eggleston have created an innovative ingredient which when applied in a suncream can act as a UVA filter and provide fuller protection against skin damage. The new compounds are light activated when exposed to relevant doses of UVA, and unique in how they release anti-oxidants to neutralise free radicals whilst at the same time capturing excess iron in the skin. In the UK, over 100,000 new cases of skin cancer are diagnosed each year, of which 10,000 are malignant melanoma - the deadliest form of the disease and also the fifth most common cancer in the UK. This research could soon be helping to better protect skin and reduce the number of cases of this type of cancer.

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Charareh Pourzand from the Department of Pharmacy and Pharmacology

Further details about TEDxBathUniversity event:

http://www.tedxbathuniversity.com

Further details about our research:

http://www.bath.ac.uk/research/news/2013/08/21/light-activated-suncream/