PharmNews

News from Pharmacy and Pharmacology at the University of Bath

The fate of Mandelic Acid in Human Cells

📥  Research

The latest paper from the research group of Matthew Lloyd and colleagues, looking at the processing of a chemical called mandelic acid. Mandelic acid, an alpha-hydroxyacid, is used in the cosmetics industry in chemical skin peels.

matthew_lloyd

Matthew Lloyd

Mandelic acid exists as two different mirror image forms (known as theĀ R- and S- enantiomers). In humans and other mammals it has been known for a long time that S-mandelic acid is converted into R-mandelic acid but not vice versa. Other workers proposed that this process was carried out by the same pathway that performs a similar transformation with anti-inflammatory drug Ibuprofen. This latest paper investigates this proposal and shows that mandelic acid is not processed by the same pathway as Ibuprofen.

The paper is the first from the work of Maksims Yevglevskis on this project, who is in the final stages of his PhD in the Department. Three of the other authors, Cat Bowskill, Chloe Chan and Justin Heng, performed work reported in this paper as part of their final year project (2012-13) for their Masters in Pharmacy degree.

The paper can be found at:

http://pubs.rsc.org/en/Content/ArticleLanding/2014/O/C3OB42515K#!divAbstract

 

 

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