{"id":315,"date":"2018-08-01T15:50:54","date_gmt":"2018-08-01T15:50:54","guid":{"rendered":"http:\/\/blogs.bath.ac.uk\/pmdlce20\/?p=315"},"modified":"2018-08-01T15:50:54","modified_gmt":"2018-08-01T15:50:54","slug":"paper-on-sinw-fets-for-prostate-cancer","status":"publish","type":"post","link":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/2018\/08\/01\/paper-on-sinw-fets-for-prostate-cancer\/","title":{"rendered":"Paper on SiNW FETs for prostate cancer"},"content":{"rendered":"<p><span style=\"color: #000000;font-family: Calibri\">Highly sensitive electrical detection of biomarkers for the early stage screening of cancer is desired for future, ultrafast diagnostic platforms. In the case of prostate cancer (PCa), the prostate-specific antigen (PSA) is of prime interest and its detection in combination with other PCa-relevant biomarkers in a multiplex approach is advised. Toward this goal, we demonstrate the label-free, potentiometric detection of PSA with silicon nanowire ion-sensitive field-effect transistor (Si NW-ISFET) arrays. The platform was used for quantitative detection of PSA using DNA aptamers as recognition elements. In the future, our platform could be utilized to detect multiple biomarkers in one assay to obtain more reliable cancer diagnostic information. <\/span><\/p>\n<p>&nbsp;<\/p>\n<p><span style=\"color: #000000;font-family: Calibri\">Dipti Rani, Vivek Pachauri, Narayanan Madaboosi, Pawan Jolly, Xuan-Thang Vu, Pedro Estrela, Virginia Chu, Joa\u0303o Pedro Conde, Sven Ingebrandt:<\/span><\/p>\n<p><span style=\"color: #000000;font-family: Calibri\">\u201cTop-Down Fabricated Silicon Nanowire Arrays for Field-Effect Detection of Prostate-Specific Antigen\u201d<\/span><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1021\/acsomega.8b00990\" target=\"_blank\" rel=\"noopener\"><strong><span style=\"color: #000000;font-family: Calibri\"><em>ACS Omega<\/em> 3 (2018) 8471-8482<\/span><\/strong><\/a><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Highly sensitive electrical detection of biomarkers for the early stage screening of cancer is desired for future, ultrafast diagnostic platforms. In the case of prostate cancer (PCa), the prostate-specific antigen (PSA) is of prime interest and its detection in combination...<\/p>\n","protected":false},"author":117,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[4],"tags":[],"class_list":["post-315","post","type-post","status-publish","format-standard","hentry","category-papers"],"acf":[],"jetpack_featured_media_url":"","_links":{"self":[{"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/posts\/315","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/users\/117"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/comments?post=315"}],"version-history":[{"count":0,"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/posts\/315\/revisions"}],"wp:attachment":[{"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/media?parent=315"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/categories?post=315"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/blogs.bath.ac.uk\/pmdlce20\/wp-json\/wp\/v2\/tags?post=315"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}