Multimodal sensing methods have a great promise in biosensing applications as they can measure independently several properties that characterise the biomolecular interaction to be detected as well as providing inherent on-chip validation of the sensing signals. This work describes the mechanisms of a concept of insulator–semiconductor field-effect devices coupled with nanoplasmonic sensing as a promising technology, which can be used for a wide range of analytical sensing applications. The work enables the development of platforms to be used for screening kinase inhibitors, which constitute an important class of chemotherapy drugs, and as a dual mode electro-optical biosensor for routine bio/chemical sensing applications.
Nikhil Bhalla, Pedro Estrela:
"Exploiting the signatures of nanoplasmon-exciton coupling on proton sensitive insulator-semiconductor devices for drug discovery applications"